A ONE-YEAR PILOT STUDY COMPARING DIRECT-INFUSION HIGH RESOLUTION MASS SPECTROMETRY BASED UNTARGETED METABOLOMICS TO TARGETED DIAGNOSTIC SCREENING FOR INHERITED METABOLIC DISEASES

Background: Early diagnosis of inherited metabolic diseases (IMDs) is important because treatment may lead to reduced mortality and improved prognosis.Due to their diversity, it is a challenge to diagnose IMDs in time, effecting an emerging need for a comprehensive test to acquire an overview of metabolite status.Untargeted metabolomics has proven

Abstract The association between the footwear microclimate and microbial community on the foot plantar skin was investigated by experiments with three participants.Novel methods were developed for measuring in-shoe temperature and humidity at five footwear regions, as well as the overall ventilation rate inside the footwear.Three types of footwear

For single-rotor helicopters there are special flight modes, when tail rotor (TR) is under significant inductive influence of vortical wake of main rotor (MR).Inductive influence of vortical wake of MR can provoke essential changes in flowing of TR and its aerodynamic characteristics comparing to isolated rotor.In this case increase of tail rotor p

The article deals ROUND BRUSH with methodology of a system failure rate calculation that is based on the adoption of the condition l.t<<1.Assuming that the condition is satisfied, the serial-parallel system failure rate calculation is easier and the results are either the same or worse from a view of system reliability evaluation.So the resul